Metformin Combined With Chemotherapy and/or Immunotherapy in Solid Malignancies
Phase PHASE1 · RECRUITING · Sponsor: Barbara Ann Karmanos Cancer Institute
NAD+ — Evidence
Clinical trials and publications sourced from ClinicalTrials.gov, PubMed, and FDA. Updated hourly by the automated crawler.
ClinicalTrials.gov (8)
Lenalidomide for Adult Histiocyte Disorders
Phase PHASE2 · ACTIVE_NOT_RECRUITING · Sponsor: Dana-Farber Cancer Institute
Impacts of Nicotinamide Riboside on Functional Capacity and Muscle Physiology in Older Veterans
Phase NA · ACTIVE_NOT_RECRUITING · Sponsor: VA Office of Research and Development
Changing the Natural History of Type 2 Diabetes ("CHANGE" Study)
Phase NA · ACTIVE_NOT_RECRUITING · Sponsor: Foundation for Atlanta Veterans Education and Research, Inc.
Psychosocial Mobile App for Chronic Graft-Versus-Host Disease
Phase NA · ACTIVE_NOT_RECRUITING · Sponsor: Massachusetts General Hospital
Double-blind Placebo Controlled Study to Evaluate the Effect of NAD+ Boosting With Nicotinamide Riboside on Immunometabolism and Immunity in Systemic Lupus Erythematosus
Phase PHASE1/PHASE2 · RECRUITING · Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
NAD Augmentation to Prevent or Reverse Alzheimer's Disease in People With Down Syndrome
Phase PHASE1 · NOT_YET_RECRUITING · Sponsor: Brigham and Women's Hospital
Gut Microbiome and Metabolic Health Study
Phase PHASE2 · RECRUITING · Sponsor: RDC Clinical Pty Ltd
PubMed (16)
Plastid G6PD3 and cytosolic G6PD5/6 are involved in the Ustilago sp. HFJ311-enhanced tolerance to cadmium stress in Arabidopsis.
BMC plant biology · 2026 Jul 17 · DOI: 10.1186/s12870-026-09534-2
Targeting Sirtuin Signaling in Parkinson's Disease and Neurodegeneration: Molecular Insights and Translational Potential.
Molecular neurobiology · 2026 Jul 17 · DOI: 10.1007/s12035-026-06062-w
Multi-module immobilization of Gluconobacter frateurii alcohol dehydrogenase and Lactobacillus brevis NADH oxidase with tethered nicotinamide adenine dinucleotide for D-allulose biosynthesis.
International journal of biological macromolecules · 2026 Jul 17 · DOI: 10.1016/j.ijbiomac.2026.153590
SLC25A51 and mitochondrial NAD⁺ transport in acute myeloid leukemia: mechanisms, therapeutic potential, and translational perspectives.
Human cell · 2026 Jul 19 · DOI: 10.1007/s13577-026-01428-7
NOX4 promotes wear particle-stimulated inflammation and osteolysis by ROS-dependent NLRP3 inflammasome activation.
Pakistan journal of pharmaceutical sciences · 2026 Oct · DOI: 10.36721/PJPS.2026.39.10.287.1
Decoding lactate signals in Alzheimer's disease: redox control, receptor pharmacology, lactylation chemistry, and neuroglial vulnerability.
Biochemical pharmacology · 2026 Jul 20 · DOI: 10.1016/j.bcp.2026.118275
Numerical simulation of mitochondrial systems for ATP generation and membrane transport.
Scientific reports · 2026 Jul 20 · DOI: 10.1038/s41598-026-61463-0
Metabolite-Specific Reproducibility of Cerebral (31)P-MRS at 3 T: Implications for Clinical Research.
NMR in biomedicine · 2026 Sep · DOI: 10.1002/nbm.70362
A phase-II randomized controlled pilot study of nicotinamide riboside supplementation in older adults with amnestic mild cognitive impairment.
Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026 Jul · DOI: 10.1002/alz.71605
Heat stress-induced degradation of glutamine synthetase rebalances central carbon-nitrogen metabolism and promotes thermotolerance in Ganoderma lucidum.
Applied and environmental microbiology · 2026 Jul 21 · DOI: 10.1128/aem.00602-26
Dual compartment lipid carriers hijack exocytosis to empower natural killer cells against solid tumours.
Nature communications · 2026 Jul 21 · DOI: 10.1038/s41467-026-75852-6
The role of redox state in regulating plant secondary metabolism under stress.
Functional plant biology : FPB · 2026 Jul 24 · DOI: 10.1071/FP25221
SIRT Family: Biological Functions and Therapeutic Targets.
MedComm · 2026 Aug · DOI: 10.1002/mco2.70866
Conformational diversity and interaction signatures of NADH across protein families.
Journal of biomolecular structure & dynamics · 2026 Jul 23 · DOI: 10.1080/07391102.2026.2704108
Targeting the NAD(+) salvage pathway: Identification of bifunctional NAMPT inhibitors and SIRT1 activators through pharmacophore-based virtual screening.
Bioorganic & medicinal chemistry · 2026 Jul 19 · DOI: 10.1016/j.bmc.2026.118754
Targeting chordoma via an isocitrate dehydrogenase-1-dependent susceptibility to redox metabolism.
Acta neuropathologica · 2026 Jul 23 · DOI: 10.1007/s00401-026-03048-9