CompoundedGuide

Regulatory Status Updates

Live feed of FDA, ClinicalTrials.gov, and PubMed changes affecting tracked peptides. Automatically updated hourly.

PubMed New record

Synergistic cardioprotection by liraglutide and deferoxamine against doxorubicin-induced cardiotoxicity via modulation of ACSL-4/Nrf-2/GPX-4 signaling.

Naunyn-Schmiedeberg's archives of pharmacology · 2026 Jul 18 · DOI: 10.1007/s00210-026-05646-6

Affected record: liraglutide · ID: 42470452
PubMed New record

GLP-1 receptor agonists in multiple sclerosis: a systematic review of preclinical and clinical evidence.

Multiple sclerosis and related disorders · 2026 Jul 10 · DOI: 10.1016/j.msard.2026.107388

Affected record: liraglutide · ID: 42470876
PubMed New record

Respiratory Adverse Events of Weight-Loss Drugs: A Systematic Review and Meta-Analysis.

Annals of the American Thoracic Society · 2026 Jul 21 · DOI: 10.1093/annalsats/aaoag177

Affected record: liraglutide · ID: 42479131
PubMed New record

A systematic review and meta-analyses of glucagon-like peptide-1 receptor agonists in acute myocardial infarction.

The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2026 Jul 21 · DOI: 10.1186/s43044-026-00767-y

Affected record: liraglutide · ID: 42479368
PubMed New record

GLP-1 Receptor Agonists as a Candidate Treatment for Opioid Use Disorder: From rats to humans.

Biological psychiatry · 2026 Jul 21 · DOI: 10.1016/j.biopsych.2026.06.033

Affected record: liraglutide · ID: 42480803
PubMed New record

Safety Signals of GLP-1 Receptor Agonists: A Multi-Method Pharmacovigilance Analysis of FAERS (2018-2025) With Sensitivity-Stratified Prioritisation, Notoriety-Bias Assessment, and Cross-Database Validation.

Diabetes, obesity & metabolism · 2026 Jul 21 · DOI: 10.1111/dom.71138

Affected record: liraglutide · ID: 42481928
PubMed New record

Glucagon-Like Peptide-1 Receptor Agonists in Orthopedics: A Scoping Review of Emerging Applications.

Indian journal of orthopaedics · 2026 Jul · DOI: 10.1007/s43465-025-01614-z

Affected record: liraglutide · ID: 42483241
PubMed New record

Pharmacologic Treatments for MASLD: A Review of Efficacy and Safety Considerations.

The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians · 2026 Jul 20 · DOI: 10.1177/87551225261466571

Affected record: liraglutide · ID: 42483637
PubMed New record

Weight Loss Following Liraglutide Therapy in a Patient With Smith-Magenis Syndrome: A Case Report.

Cureus · 2026 Jun · DOI: 10.7759/cureus.111313

Affected record: liraglutide · ID: 42488278
PubMed New record

GLP-1 receptor agonists in Parkinson's disease: a meta-analysis revealing motor benefit and highlighting mood improvement.

Frontiers in neurology · 2026 · DOI: 10.3389/fneur.2026.1858507

Affected record: liraglutide · ID: 42490867
PubMed New record

Clinical efficacy of liraglutide combined with pioglitazone in obese polycystic ovary syndrome and its effects on the serum chemerin/visfatin ratio.

American journal of translational research · 2026 · DOI: 10.62347/WNDZ4386

Affected record: liraglutide · ID: 42491030
PubMed New record

A survey of primary care physicians' views on supporting patients who lose insurance coverage for Glucagon-Like Peptide-1-based drugs for weight management.

Obesity pillars · 2026 Sep · DOI: 10.1016/j.obpill.2026.100304

Affected record: liraglutide · ID: 42494804
PubMed New record

Efficacy and Safety of Once-Weekly Semaglutide Versus Basal Insulin and Other GLP-1 Receptor Agonists in Adults With Type 2 Diabetes Uncontrolled on Oral Antidiabetic Drugs: A Systematic Review and Pairwise Meta-Analysis.

Cureus · 2026 Jun · DOI: 10.7759/cureus.111363

Affected record: liraglutide · ID: 42495484
PubMed New record

Circulating levels of PYY are increased in individuals with bile acid diarrhoea.

The Journal of clinical endocrinology and metabolism · 2026 Jul 24 · DOI: 10.1210/clinem/dgag295

Affected record: liraglutide · ID: 42496159
ClinicalTrials.gov New record

Determination of Resistance Training Status for Patients on Glucagon-Like Peptide-1 Receptor Agonists

Phase N/A · RECRUITING · Sponsor: Ohio State University

Affected record: liraglutide · ID: NCT07702461
ClinicalTrials.gov New record

Determination of Resistance Training Status for Patients on Glucagon-Like Peptide-1 Receptor Agonists

Phase N/A · RECRUITING · Sponsor: Ohio State University

Affected record: semaglutide · ID: NCT07702461
ClinicalTrials.gov Status change

A Research Study to Look at How Well CagriSema Helps People Living With Obesity Lose Weight and Maintain Weight Loss in the Long-term

Phase PHASE3 · ACTIVE_NOT_RECRUITING · Sponsor: Novo Nordisk A/S

Affected record: semaglutide · ID: NCT07011667
ClinicalTrials.gov New record

MODERN-Dental: Pediatric Obesity, Cardiometabolic Risks, And Periodontal Disease

Phase NA · NOT_YET_RECRUITING · Sponsor: Oelisoa Andriankaja

Affected record: semaglutide · ID: NCT07478653
ClinicalTrials.gov New record

A Study to Assess the Efficacy, Safety and Tolerability of AT673 Co-administered With Semaglutide in Adult Participants With Type 2 Diabetes (T2D) and Overweight or Obesity

Phase PHASE2 · RECRUITING · Sponsor: Antag Therapeutics

Affected record: semaglutide · ID: NCT07724340
ClinicalTrials.gov New record

GLP-1R Agonist Treatment for Opioid Use Disorder

Phase PHASE2 · RECRUITING · Sponsor: Milton S. Hershey Medical Center

Affected record: semaglutide · ID: NCT06548490
PubMed New record

Respiratory Adverse Events of Weight-Loss Drugs: A Systematic Review and Meta-Analysis.

Annals of the American Thoracic Society · 2026 Jul 21 · DOI: 10.1093/annalsats/aaoag177

Affected record: tirzepatide · ID: 42479131
PubMed New record

GLP-1 Receptor Agonists as a Candidate Treatment for Opioid Use Disorder: From rats to humans.

Biological psychiatry · 2026 Jul 21 · DOI: 10.1016/j.biopsych.2026.06.033

Affected record: tirzepatide · ID: 42480803
PubMed New record

Association between GLP-1 receptor agonists and alcohol-related hospitalisations among adults with alcohol use disorder: multi-target trial emulation study.

BMJ open · 2026 Jul 21 · DOI: 10.1136/bmjopen-2025-109259

Affected record: tirzepatide · ID: 42481079
PubMed New record

Cardiovascular Outcomes of GLP-1-Based Medicines Among People With Overweight and Obesity: An Umbrella Review of Meta-Analyses of Randomized Controlled Trials.

Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026 Jul 22 · DOI: 10.1111/obr.70198

Affected record: tirzepatide · ID: 42483841
PubMed New record

Multi-target-directed drugs: new additions in 2025 and post-marketing safety surveillance of drugs marketed in 2022-2024.

Pharmacological reports : PR · 2026 Jul 22 · DOI: 10.1007/s43440-026-00879-x

Affected record: tirzepatide · ID: 42484993
PubMed New record

Comparative Efficacy and Safety of Tirzepatide in Asian and Non-Asian Adults With Obesity Without Diabetes: A Systematic Review and Meta-Analysis.

Endocrinology, diabetes & metabolism · 2026 Jul · DOI: 10.1002/edm2.70291

Affected record: tirzepatide · ID: 42487213
PubMed New record

Hypersensitivity Reaction to Tirzepatide With Demonstrated Tolerance to Semaglutide: A Case Report.

Clinical case reports · 2026 Jul · DOI: 10.1002/ccr3.73183

Affected record: tirzepatide · ID: 42487660
PubMed New record

Personalization of incretin therapy: can GLP-1 and GIP receptor polymorphisms influence therapy response?

Journal of the Endocrine Society · 2026 Aug · DOI: 10.1210/jendso/bvag149

Affected record: tirzepatide · ID: 42487666
PubMed New record

Effects of tirzepatide therapy on body weight and body composition in adults with overweight and obesity.

Frontiers in endocrinology · 2026 · DOI: 10.3389/fendo.2026.1834580

Affected record: tirzepatide · ID: 42488012
PubMed New record

Cardiovascular and Cerebrovascular Outcomes Risk Reduction Associated With Semaglutide vs Tirzepatide: A Target Trial Emulation.

JACC. Advances · 2026 Jul · DOI: 10.1016/j.jacadv.2026.102917

Affected record: tirzepatide · ID: 42489387
PubMed New record

Real-world treatment satisfaction and experience with once-weekly tirzepatide: Insights from prescribing physicians and people with obesity or overweight.

Obesity pillars · 2026 Sep · DOI: 10.1016/j.obpill.2026.100300

Affected record: tirzepatide · ID: 42491427
PubMed New record

One receptor, two opposite approaches: efficacy and tolerability of GIPR agonism and antagonism in obesity pharmacotherapy.

Appetite · 2026 Jul 23 · DOI: 10.1016/j.appet.2026.108723

Affected record: tirzepatide · ID: 42492687
ClinicalTrials.gov New record

Tirzepatide s Dopaminergic Effects in Alcohol Use Disorders (AUD)

Phase PHASE1 · RECRUITING · Sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Affected record: tirzepatide · ID: NCT07559500
ClinicalTrials.gov New record

Determination of Resistance Training Status for Patients on Glucagon-Like Peptide-1 Receptor Agonists

Phase N/A · RECRUITING · Sponsor: Ohio State University

Affected record: tirzepatide · ID: NCT07702461
ClinicalTrials.gov Status change

GLP-1R Actions on Muscle and the Skeleton

Phase PHASE4 · ACTIVE_NOT_RECRUITING · Sponsor: Pennington Biomedical Research Center

Affected record: tirzepatide · ID: NCT07154719
ClinicalTrials.gov New record

Different Medications to Induce Labor

Phase PHASE3 · RECRUITING · Sponsor: Icahn School of Medicine at Mount Sinai

Affected record: oxytocin · ID: NCT06259097
ClinicalTrials.gov New record

Metformin Combined With Chemotherapy and/or Immunotherapy in Solid Malignancies

Phase PHASE1 · RECRUITING · Sponsor: Barbara Ann Karmanos Cancer Institute

Affected record: nad-plus · ID: NCT07098299
PubMed New record

The STRIDE Trial and Semaglutide: Implications for Clinical Vascular Practice.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery · 2026 Jul 16 · DOI: 10.1016/j.ejvs.2026.07.037

Affected record: semaglutide · ID: 42462869
PubMed New record

Semaglutide vs. liraglutide and incidence of diabetes and cardiovascular disease: A target trial emulation using real-world data.

British journal of clinical pharmacology · 2026 Jul 16 · DOI: 10.1002/bcp.70711

Affected record: semaglutide · ID: 42464447
PubMed New record

Trends in Usage and Payments for Glucagon-Like Peptide-1 Receptor Agonists in the United States, 2017 to 2022: A Nationally Representative Repeated Cross-Sectional Study.

Journal of the American Heart Association · 2026 Jul 17 · DOI: 10.1161/JAHA.125.046302

Affected record: semaglutide · ID: 42464889
PubMed New record

Urological Complications of Morbid Obesity and the Role of Bariatric Surgery and Glucagon-Like Peptide-1 Receptor Agonists in Their Management: A Systematic Review.

Cureus · 2026 Jun · DOI: 10.7759/cureus.110952

Affected record: semaglutide · ID: 42465136
PubMed New record

Semaglutide-Induced Ischemic Colitis in A Middle-Aged Female Without Vascular Risk Factors.

European journal of case reports in internal medicine · 2026 · DOI: 10.12890/2026_006649

Affected record: semaglutide · ID: 42466220
PubMed New record

Incretin-based cardiovascular protection beyond diabetes: evidence, mechanisms, and therapeutic frontiers from GLP-1 receptor agonists to multi-agonist therapy.

Frontiers in endocrinology · 2026 · DOI: 10.3389/fendo.2026.1870649

Affected record: semaglutide · ID: 42466348
PubMed New record

Effect of semaglutide on hidradenitis suppurativa disease control and quality of life: A case series.

Journal of the European Academy of Dermatology and Venereology : JEADV · 2026 Jul 17 · DOI: 10.1111/jdv.70614

Affected record: semaglutide · ID: 42466886
PubMed New record

Peripheral artery disease: advances in medical therapy.

European heart journal · 2026 Jul 17 · DOI: 10.1093/eurheartj/ehag516

Affected record: semaglutide · ID: 42466921
PubMed New record

Evolving utilization of bariatric surgery since the rise of semaglutide and tirzepatide.

Surgical endoscopy · 2026 Jul 17 · DOI: 10.1007/s00464-026-13147-z

Affected record: semaglutide · ID: 42467193
PubMed New record

Postshortage Compounded GLP-1 RA Market in 2 States With Potentially High Demand.

JAMA health forum · 2026 Jul 2 · DOI: 10.1001/jamahealthforum.2026.2207

Affected record: semaglutide · ID: 42467450
PubMed New record

N-terminally modified GLP1R agonists drive G protein bias via extracellular loop 3 displacement.

Cell reports · 2026 Jul 17 · DOI: 10.1016/j.celrep.2026.117718

Affected record: semaglutide · ID: 42467532
PubMed New record

Glucagon-like peptide-1 receptor agonists in the aging population of people with HIV: emerging evidence and clinical implications.

Current opinion in HIV and AIDS · 2026 Jul 17 · DOI: 10.1097/COH.0000000000001059

Affected record: semaglutide · ID: 42467949
PubMed New record

Therapeutic Benefit or Ocular Risk? Semaglutide and Non-Arteritic Anterior Ischemic Optic Neuropathy: Retraction.

Retina (Philadelphia, Pa.) · 2026 Aug 1 · DOI: 10.1097/IAE.0000000000004884

Affected record: semaglutide · ID: 42468029